Obligation for registered natural persons, legal entities and public authorities to inform the Ministry of Health by 31 March each year whether they continue the activities for which they have been registered. This information can only be submitted on a form, the model of which is set out in the implementing legislation (Decree 54/2014 Coll.). If natural persons, legal entities or public authorities cease to carry out all the activities for which they were registered, they may notify the Ministry of Health in writing. This notification shall cancel the registration or special registration of the natural person, legal entity or public administration body.

Natural persons, legal entities and state administration bodies which in a calendar month placed on the market of the Czech Republic or another Member State of the European Union a selected listed substance of category 1 or 2 (Acetanhydride) in a quantity exceeding the limit quantity (100 kg per calendar year) set by the implementing legislation (Decree No. 54/2014 Coll.), they are obliged to submit a monthly summary report on this to the Ministry of Health, which shall be submitted on the form, the model of which is set out in the implementing regulation, by the 15th day of the following calendar month. Substances of category 1,2 are listed in Annex I to REGULATION (EC) No 273/2004 OF THE EUROPEAN PARLIAMENT AND OF THE COUNCIL of 11 February 2004 on drug precursors.

Natural persons, legal entities and state administration bodies are obliged to provide the Ministry of Health with summary data on the activities with the specified substance of category 1, 2 or 3 in accordance with directly applicable European Union regulations on forms, the models of which are laid down by implementing legislation (Decree No 54/2014 Coll.). Substances of category 1-3 are listed in Annex I to REGULATION (EC) No 273/2004 OF THE EUROPEAN PARLIAMENT AND OF THE COUNCIL of 11 February 2004 on drug precursors.

Natural persons, legal entities and state administration bodies that have been issued a licence to manufacture a Category 1 substance shall be obliged to notify the Ministry of Health of the total estimate of Category 1 substances and the quantities they intend to manufacture on the basis of the licence in the year of issue of the licence and in the year following the year of issue of the licence, immediately after the licence has been issued. In the years following the year of issue of the licence, natural persons, legal persons and public authorities shall be obliged to communicate to the Ministry of Health the total estimate of the Category 1 substances listed and the quantities they intend to manufacture under the licence in the following year, by 30 April each year for the duration of the licence. The communication of the estimate shall be made on a form the model of which is laid down in the implementing legislation. Category 1 substances are listed in Annex I to REGULATION (EC) No 273/2004 OF THE EUROPEAN PARLIAMENT AND OF THE COUNCIL of 11 February 2004 on drug precursors.

Natural persons, legal entities and state administration bodies supplying to the market of the Czech Republic or other Member States of the European Union a starting or auxiliary substance in a quantity which, in its sum over the course of one year for one starting or auxiliary substance, exceeds the quantitative limit set by the implementing legislation (Decree No. 54/2014 Coll.), they are obliged to report monthly to the Ministry of Health the quantity of supplied starting and auxiliary substances with the indication of the purchaser on the form, the model of which is set out in the implementing regulation, by the 15th day of the following calendar month.